Modeling — Question 6

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Question 6

In an idealized closed-population epidemic model, s,i,rs,i,r are susceptible, infectious and removed fractions. There are no births, deaths or reinfections. Homogeneous mixing gives new infections at rate 2si2si per day and removal at rate ii per day. Initially (s,i,r)=(0.99,0.01,0)(s,i,r)=(0.99,0.01,0), and tt is in days. Assume the stated rates remain constant throughout the modeled outbreak.

Tasks

  1. Derive the three balance equations and explain conservation and nonnegativity. Reduce to two independent states.

  2. Eliminate time to derive a relation between ii and ss. Find the susceptible fraction and infectious fraction at the unique infectious peak; justify that this peak is reached.

  3. Show i(t)→0i(t)\to 0 and s(t)→s∞>0s(t)\to s_\infty>0. Derive an equation uniquely selecting s∞s_\infty in (0,1/2)(0,1/2) and estimate it to three decimals.

  4. Sketch the physical path in the (s,i)(s,i) plane with equal scales, its initial point, peak and limiting endpoint. Explain why the peak condition does not mean infections have ended.

Original worksheet page 1: question and worked solution for 5-12-006
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Question 6 – Solution

Strategy. Conservation confines the dynamics; eliminating time gives an exact curve and identifies both the peak and final-size constraint.

Step 1: Balance the three populations. The equations are s′=−2si,i′=2si−i,r′=i\boxed{s'=-2si,\ i'=2si-i,\ r'=i}, with s+i+r=1s+i+r=1. Boundary rates cannot create negative fractions. More explicitly, s=0.99e−2∫0tis=0.99e^{-2\int_0^t i} and i=0.01e∫0t(2s−1)i=0.01e^{\int_0^t(2s-1)} are positive at finite times; r′=i≥0r'=i\ge 0. Use r=1−s−ir=1-s-i to reduce the system.

Step 2: Eliminate time and locate the peak. Since s,i>0s,i>0, di/ds=−1+1/(2s)di/ds=-1+1/(2s). Integrating through the initial point gives i=1−s+12log⁡(s/0.99).\boxed{i=1-s+\tfrac 12\log(s/0.99).} Here i′=i(2s−1)i'=i(2s-1) changes sign at s=1/2s=1/2. This value must be reached: if s≥1/2s\ge 1/2 forever, then i≥0.01i\ge 0.01 and s′≤−0.02ss'\le-0.02s, a contradiction. Strict decrease of ss permits only one crossing. Hence imax=12+12log⁡(0.5/0.99)≈0.15845\boxed{i_{\max}=\tfrac 12+\tfrac 12\log(0.5/0.99)\approx 0.15845}.

Step 3: Identify the physical final size. Because ∫0∞i=r∞≤1\int_0^\infty i=r_\infty\le 1, s≥0.99e−2>0s\ge 0.99e^{-2}>0. Thus decreasing ss has a positive limit. Also ii is integrable and has a bounded derivative on the invariant simplex, so i→0i\to 0: nonvanishing peaks would have widths bounded below and contradict integrability. The peak crossing implies s∞<1/2s_\infty<1/2. Substitution gives 1−s∞+12log⁡(s∞/0.99)=0,s∞≈0.200.\boxed{1-s_\infty+\tfrac 12\log(s_\infty/0.99)=0,\quad s_\infty\approx 0.200.} On (0,1/2)(0,1/2) the left side is strictly increasing, tends to −∞-\infty at zero and is positive at 1/21/2, so this root is unique.

Step 4: Interpret the physical trajectory. Time moves toward smaller ss, up to the peak and then down toward zero infectious fraction. The limiting endpoint is open because i(t)>0i(t)>0 at finite times. At the peak, incidence and removal balance; both are positive. The peak marks zero net infectious growth, not the end of infection.

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Original worksheet page 2: question and worked solution for 5-12-006

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